FBI Special Agent Don Eppes recruits his mathematically gifted brother, Charlie, to help the Bureau solve a wide range of challenging crimes in Los Angeles. Don is assisted by fellow agents Megan Reeves, David Sinclair, and Colby Granger, while Charlie finds insight and encouragement from a co-worker, Dr. Larry Fleinhardt, and Amita Ramanujan, Charlie's former grad student.

Drama about an FBI agent who recruits his mathematical-genius brother to help the Bureau solve a wide range of challenging crimes in Los Angeles. The two brothers take on the most confounding criminal cases from a very distinctive perspective. Inspired by actual events, the series depicts how the confluence of police work and mathematics provides unexpected revelations and answers to the most perplexing criminal questions.